| Main Title |
Morphometric and Electrophysiological Evidence for a Diameter-Based Rate of Degeneration in the Optic Nerve of the Rat (Journal Version). |
| Author |
Veronesi, B. ;
Boyes, W. K. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
1988 |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/152; |
| Stock Number |
PB89-110480 |
| Additional Subjects |
Morphology ;
Electrophysiology ;
Optic nerve ;
Laboratory animals ;
Rats ;
Deterioration ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-110480 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
16p |
| Abstract |
The diameter-based rate of degeneration in the rat's optic nerve was examined using coordinated morphological and electrophysiological techniques. Long-Evans male rats were implanted with indwelling stimulating electrodes in the optic chiasm and recording electrodes in the stratum opticum of the superior colliculus. After one week, enucleation was performed on one optic nerve with the unoperated side serving as the control. In another set of identically treated rats, morphological analysis of the optic nerve over D-0-7 was performed. A linear regression analysis revealed an exponential rate of degeneration as a direct function of axonal diameter, that is the number of fibers. |
