Record Display for the EPA National Library Catalog


Main Title Experimental Pulmonary Emphysema Induced in the Rat by Intratracheally Administered Elastase: Morphogenesis.
Author Busch, R. H. ; Lauhala, K. E. ; Loscutoff, S. M. ; McDonald, K. E. ;
CORP Author Battelle Pacific Northwest Labs., Richland, WA.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/067;
Stock Number PB84-232685
Additional Subjects Respiratory diseases ; Emphysema ; Pulmonary emphysema ; Rats ; Laboratory animals ; Dosage ; Toxicity ; Reprints ; Elastase ; Morphogenesis
Library Call Number Additional Info Location Last
NTIS  PB84-232685 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 19p
Emphysema was produced experimentally in rats by administration of porcine pancreatic elastase at dose levels of 75, 100, 125, and 150 units elastase activity/100 g body wt. All doses studied were equally effective in producing emphysema. Dose levels of over 75 units activity/100 g offered no advantage in terms of degree or severity of emphysema produced; however, such doses exacerbated hemorrhage and edema, resulting in relatively high post-instillation mortality. Lesion morphogenesis at all doses tested paralleled those described in this and in other species by other investigators. The 75-unit activity produced a quantifiable degree of emphysema which was relatively constant among animals. Results suggest that because of group differences in susceptibility to elastase (or variations in batches of elastase), dose-range studies should be performed on each new group of animals.