Record Display for the EPA National Library Catalog

RECORD NUMBER: 33 OF 33

Main Title Use of Molecular Negentropy to Encode Structure Governing Biological Activity.
Author Kier, L. B. ;
CORP Author Virginia Commonwealth Univ., Richmond.;Environmental Research Lab.-Duluth, MN.
Year Published 1980
Report Number EPA-R-808923; EPA-600/J-80-436;
Stock Number PB84-116714
Additional Subjects Drugs ; Molecules ; Tissues(Biology) ; Information ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB84-116714 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Abstract
A drug molecule is considered to be an information source with an information content available to receptive tissue. In nonspecific interactions, much of the information content has quality as judged by the receptor. Quantitation of the information content using Shannon's equation gives the molecular negentropy. This index is shown to rank molecules according to symmetry and to encode structural characteristics influencing physical properties and biological activity in certain cases.