| Main Title |
Identification of Deoxynucleoside; Polyaromatic Hydrocarbon Adducts by Capillary Zone Electrophoresis; Continuous Flow-Fast Atom Bombardment Mass Spectrometry. |
| Author |
Wolf, S. M. ;
Vouros, R. ;
Norwood, C. ;
Jackim, E. ;
|
| CORP Author |
Northeastern Univ., Boston, MA. Barnett Inst. of Chemical Analysis and Materials Science.;Environmental Research Lab., Narragansett, RI.;National Institutes of Health, Bethesda, MD.;Arthur D. Little Foundation, Cambridge, MA.;Society of Analytical Chemists of Pittsburgh, PA. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
PUB-509; EPA/600/J-93/314 ; ERLN-1416 |
| Stock Number |
PB93-229367 |
| Additional Subjects |
Deoxyguanosine ;
Aromatic polycyclic hydrocarbons ;
Electrophoresis ;
Fast atom bombardment mass spectrometry ;
Mutagens ;
Molecular weight ;
DNA damage ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-229367 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Capillary zone electrophoresis coupled to continuous flow-fast atom bombardment mass spectrometry is shown to have utility for the detection and characterization of adducts formed by the covalent attachment of four polyaromatic hydrocarbon (PAH) and amino-PAH compounds to deoxyguanosine. Normal scanning provided structural information for a 1.3 ng injection of a model adduct, while 1.3 ng of each of a mixture of adducts was sufficient to determine their molecular weights by monitoring the constant neutral loss of deoxyribose. Exploitation of this loss in the multiple reaction monitoring mode resulted in the detection of low picogram amounts of target adducts in mixtures. (Copyright (c) 1992 American Society for Mass Spectrometry.) |
