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RECORD NUMBER: 12 OF 23

OLS Field Name OLS Field Data
Main Title Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets /
Author Boelsterli, Urs A.,
Publisher CRC Press,
Year Published 2007
OCLC Number 74459862
ISBN 9780849372728; 0849372720
Subjects Molecular toxicology. ; Toxicology--methods. ; Molecular Biology--methods. ; Signal Transduction. ; Xenobiotics--pharmacokinetics. ; Xenobiotics--toxicity. ; Toxicologia. ; Transduðcäao de sinal celular. ; Biologia molecular.
Internet Access
Description Access URL
http://www.loc.gov/catdir/enhancements/fy0703/2006035219-d.html
Table of contents http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016075542&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
Publisher description http://catdir.loc.gov/catdir/enhancements/fy0703/2006035219-d.html
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EKBM  RA1220.3.B64 2007 Research Triangle Park Library/RTP, NC 08/08/2011
ELBM  RA1220.3.B64 2007 AWBERC Library/Cincinnati,OH 08/29/2008
ELDM  RA1220.3.B64 2007 CCTE/GLTED Library/Duluth,MN 12/06/2010
Edition 2nd ed.
Collation 399 p. : ill. ; 25 cm.
Notes
Includes bibliographical references and index.
Contents Notes
Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.