Main Title |
Applied biopharmaceutics & pharmacokinetics / |
Author |
Shargel, Leon,
|
Other Authors |
|
Publisher |
McGraw-Hill Medical, |
Year Published |
2012 |
OCLC Number |
726074708 |
ISBN |
9780071603935 (hardcover : alk. paper); 007160393X (hardcover : alk. paper); 9781259011115 (International ed.); 1259011119 (International ed.) |
Subjects |
Biopharmaceutics ;
Pharmacokinetics ;
Models, Chemical
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EKBM |
RM301.4.S52 2012 |
|
Research Triangle Park Library/RTP, NC |
09/15/2014 |
|
Edition |
6th ed. |
Collation |
xviii, 811 p. : ill. ; 25 cm. |
Notes |
Includes bibliographical references and index. |
Contents Notes |
Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease -- Physiologic pharmacokinetic models, mean residence time, and statistical moment theory. |