| Main Title |
Uptake of Inorganic Lead In vitro by Isolated Mitochondria and Tissue Slices of Rat Renal Cortex. |
| Author |
Kapoor, S. C. ;
van Rossum, G. D. V. ;
O'Neill, K. J. ;
Mercorella, I. ;
|
| CORP Author |
Temple Univ., Philadelphia, PA. School of Medicine. ;Rome Univ. (Italy). Ist. di Patologia.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1985 |
| Report Number |
EPA-R-806616; EPA/600/J-85/157; |
| Stock Number |
PB86-100575 |
| Additional Subjects |
Lead(Metal) ;
Rats ;
Tissues ;
In vitro analysis ;
Mitochondria ;
Reprints ;
Heavy metals
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-100575 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
Slices of rat renal cortex were shown to take up Pb2+ during incubation in vitro; Pb2+ was also shown to enter mitochondria within the slices. The uptake of Pb2+ by isolated mitochondria was inhibited by N3-, La3+ and ruthenium red. A steady state of uptake was attained within 60 sec. The concentration dependence of uptake was complex; maximum uptake was attained at 25 micromols and inhibition ensued at higher concentrations. A substantial inhibitor-resistant component of Pb2+ uptake was noted, especially at medium Pb2+ concentrations greater than 25 micromoles, and these concentrations also inhibited respiration state 3. The effects on respiration were reduced if the mitochondria had been preincubated with ruthenium red. |
