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Main Title 'In Vitro' Effects of Mineral Fibers.
Author Palekar, L. D. ; Cook, P. M. ; Coffin, D. L. ;
CORP Author Environmental Research Lab.-Duluth, MN. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-600/J-83-221;
Stock Number PB84-212869
Additional Subjects In vivo analysis ; Toxicology ; Cost effectiveness ; Reprints ; Mineral fibers
Library Call Number Additional Info Location Last
NTIS  PB84-212869 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
In vivo tests available to determine the toxicity of mineral fibers are too expensive and time-consuming to be regularly employed in the evaluation of the potential health hazard posed by natural and man-made fibers. In vitro procedures, while economical, convenient and capable of ranking 'relative toxicity', are uncertain predictors of specific lesions. Thus, it is of interest to compare the results of various standard in vitro tests with the results of in vivo tests. Data are available for intratracheal and intrapleural exposures of animals to amphibole mineral fibers from UICC amosite and a fibrous form of ferroactinolite. This paper presents data from parallel in vitro studies employing these minerals. The methods used were mammalian erythrocyte lysis, Chinese hamster ovary cell clonal cytotoxicity assay, and rabbit alveolar macrophage cytotoxicity assay.