Genes, Transcripts and Proteins of CD137 Receptor and Ligand -- CD137 Signal Transduction -- Significance of Reverse Signal Transduction for the Biology of the CD137 Receptor/Ligand System -- CD137 Signal in the Regulation of Innate Immunity -- Regulation of T Cell-Dependent Humoral Immunity Through CD137 (4-1BB) Mediated Signals -- CD137 in the Regulation of T Cell Response to Antigen -- Autoimmune Diseases -- CD137/CD137 Ligand in Tumor and Viral Immunotherapy. This comprehensive volume, written by experts in the field, covers nearly all aspects of ongoing research related to the CD137 pathway. Recent research has shown that the manipulation of CD137 pathway molecules is very promising in the treatment of cancer, viral infection, transplantation rejection and autoimmune diseases in experimental animal models. The volume includes research related to the identification and understanding of functional consequences of CD137 receptor and ligand molecules which represents a major effort in the field of immunology. CD137 Pathway: Immunology and Diseases is an ideal book for immunologists, microbiologists, cancer researchers, molecular biologists, biochemists, and pharmaceutical and biotechnology company scientists.