| Main Title |
Initial Submission: Letter from Rohm and Haas Company to USEPA re: Preliminary Results of Acute Toxicity Test Including Neurotoxic Effects in Mice with C12-14-Tert-Alkyl Amines, with Cover Letter dated 09/30/99. |
| CORP Author |
Rohm and Haas Co., Philadelphia, PA.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
5 Oct 1999 |
| Year Published |
1999 |
| Report Number |
8EHQ-99-14562; |
| Stock Number |
OTS-0559809 |
| Additional Subjects |
Toxicity ;
Neurotoxicity ;
Amines ;
Mice ;
Laboratory animals ;
Dosage ;
C12-14-Tert-Alkyl Amines
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0559809 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
5p |
| Abstract |
This letter transmits preliminary results of acute toxicity test indicating neurotoxic effects to male and female mice for Cl2-14-tert-alkyl amines (CAS no. 68955-53-3). Three groups of 6 male and female mice received a single oral dose (gavage) Cl2-14-tert- alkyl amines in corn oil at 250, 500, and 1000 mg/kg body weight. Clinical signs of neurotoxicity (tremors, straub tail) were observed in female mice at 250 mg/kg and above and in male mice at 500 mg/kg and above. These signs were evident beginning 1 hour post-dosing and were no longer evident in surviving mice by day 1 post-dosing. Hyperactivity was also observed in a single female mouse at 500 mg/kg on day 1 only. |
