Record Display for the EPA National Library Catalog

RECORD NUMBER: 465 OF 1249

Main Title Initial Submission: Isophorone: Significance of the Toxicology and Carcinogenicity in Fischer 344 Rats and B6C3F1 Mice with Cover Letter dated 09/24/1992.
CORP Author Papanicolaou Cancer Research Inst., Miami, FL.; Union Carbide Corp., Danbury, CT.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-0992-11057
Stock Number OTS0571092
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Isophorone ; Chronic toxicity ; Carcinogenicity ; Mammals ; Rats ; Oral ; Gavage ; Mice ; CAS No 78-59-1
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS0571092 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 29p
Abstract
Isophorone when administered in corn oil and by stomach tube at dosage levels of 250 or 500 mg/kg was associated with an increased incidence of renal and preputial tumors in male rats, an increased incidence of liver tumors in male mice, but did not exhibit carcinogenic potential in either female rats or mice. Thus, under the conditions of this bioassay, isophorone appeared to exhibit weak carcinogenic activity.