| Main Title |
Cutaneous Carcinogenicity Study with Mice on the Diglycidyl Ether of 1,4-butane Diol with Attachments and Cover Letter dated 09/28/1987. |
| CORP Author |
CIBA-GEIGY Corp., Ardsley, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1987 |
| Report Number |
86-880000066 |
| Stock Number |
OTS0513957 |
| Additional Subjects |
Toxicology ;
Health effects ;
1 ;
4-butane Diol (2425-79-8) ;
Chronic Toxicity ;
Carcinogenicity ;
Mammals ;
Mice ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 2425-79-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0513957 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
53p |
| Abstract |
Dermal carcinogenicity was evaluated in groups of male and female CF1 mice (50/sex/group) receiving applications (volume not reported) of 0.05% or 0.2% (based on preliminary studies) 1,4-butanediol diglycidyl ether in acetone twice weekly to the dorsal skin for 103 weeks. Of all animals in both dose groups, 5 animals developed 6 neoplasms of the skin and subcutis; 1 control animal developed a tumor. A transient irritant reaction was observed in 37 animals with no thickening of the epidermis. A statistically significant increase in neoplasms of the treated skin was not observed. |
