Record Display for the EPA National Library Catalog

RECORD NUMBER: 4 OF 5

Main Title NTP Technical Report on the Toxicology and Carcinogenesis Studies of Methylene Blue Trihydrate (CAS No. 7220-79-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
CORP Author National Toxicology Program, Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic; Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Globals Centers for Health and Environmental Sciences.
Year Published 2008
Report Number 8EHQ-07-16715
Stock Number OTS0600505
Additional Subjects Health effects ; Methylene blue trihydrate ; Toxicity ; Rats ; Mice ; Gavage studies ; CAS No 7220-79-3 ; Toxicology ; 1-1-2-2-tetrafluoroethanesulfonic acid anhydride ; Oral toxicity
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS0600505 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1p
Abstract
Methylene blue trihydrate has a variety of biomedical and biologically therapeutic applications. Methylene blue trihydrate was nominated by the National Cancer Institute (NCI) for carcinogenicity testing based on the numerous uses of this compound and the lack of long-term toxicity data, including epidemiological studies of methylene blue trihydrate, as well as the inadequate animal data on this compound. Male and female F344/N rats and B6C3F1 mice were administered methylene blue trihydrate in 0.5% aqueous methylcellulose by gavage for 1 month, 3 months, or 2 years. Genetic toxicology studies were conducted using Salmonella typhimurium,Escherichia coli, cultured Chinese hamster ovary cells, mouse bone marrow cells, and mouse peripheral blood erythrocytes.