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Main Title Upper-bound quantitative cancer risk estimate for populations adjacent to sulfur mustard incineration facilities : final.
Author Koppikar, A. ; McGaughy, R. ; Rhomberg, L.
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency,
Year Published 1991
Report Number EPA/600/8-91/053; PB92137207
Stock Number PB92-137207
OCLC Number 24661053
Subjects Cancer ; Sulfur ; Incinerators ; Cancer--Risk factors ; Sulphur
Additional Subjects Malignant neoplasms ; Mustard gas ; Incinerators ; Chemical warfare agents ; Toxicity ; Health hazards ; Adenoma ; Pulmonary neoplasms ; Benzo(a)pyrene ; Methylcholanthrene ; Mice ; Dose-response relationships ; Carcinogenicity tests
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600/8-91/053 Headquarters Library/Washington,DC 02/20/2009
EJED  EPA-600/8-91-053 OCSPP Chemical Library/Washington,DC 07/10/1992
EKBD  EPA-600/8-91-053 Research Triangle Park Library/RTP, NC 10/11/2012
ELBD ARCHIVE EPA 600/8-91/053 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023 DISPERSAL
ERAD  EPA 600/8-91-053 Region 9 Library/San Francisco,CA 04/03/1992
ESAD  EPA 600-8-91-053 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB92-137207 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vi, 43 p.
The document characterizes the potential cancer hazard to populations residing near sulfur mustard incineration facilities while the incineration is taking place. The carcinogenicity of sulfur mustard is reviewed briefly to show what evidence has lead to the previously-accepted conclusion that sulfur mustard is a known human carcinogen. Two approaches are taken to estimate the upper-bound lifetime cancer risk per unit air concentration. The first approach is to analyze the two sulfur mustard chronic toxicity experiments in Sprague-Dawley rats reported by McNamara, et al. (1975). The second approach is to evaluate and then combine two relative potency estimates: (1) the strain A mouse lung adenoma response to the injection of sulfur mustard compared to the same response to injected 3-methyl cholanthrene as measured in two separate experiments in a relatively narrow time period, and (2) the strain A mouse lung adenoma response to 3-methyl cholanthrene and benzo(a)pyrene (BaP) in the same experiment. The conclusion is that the upper-bound individual and population risks are negligible.
"Human Health Assessment Group, Office of Health and Environmental Assessment, Office of Research and Development." "July 1991." "EPA/600/8-91/053." Includes bibliographical references.