| Main Title |
Support: Letter from Methacrylate Producers to USEPA with Additional Information re: an Acute Inhalation Toxicity Study of Ethyl and Methyl Methacrylate in Rats (8EHQ-0401-14894), as Requested by USEPA, dated 10/11/2001. |
| CORP Author |
Methacrylate Producers Association, Inc., Leesburg, VA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2001 |
| Report Number |
8EHQ-1101-14894 |
| Stock Number |
OTS0560029-1 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Ethyl methacrylate ;
Methyl methacrylate ;
CAS No 97-63-2 ;
CAS No 80-62-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0560029-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
The study was conducted with 5 male F344 rats with bodyweights between 265-295 grams. The rats were exposed to 200 ppm of ethyl methacrylate for a period of 6 hours. The rat: were killed immediately after exposure with halothane and the heads processed exactly as described for methyl methacrylate in previous studies. The nasal tissue of rats exposed to ethyl methacrylate showed slight to moderate degeneration of the olfactory epithelium lining the central septum and mid ethmo-turbinates. The effects were similar in appearance and distribution to those observed for methyl methacrylate (CAS No. 80-62-6). The respiratory mucosa throughout the nasal passages and the olfactory mucosa in regions adjacent to these areas were not affected by exposure to ethyl methacrylate. These data were presented at the last SOT meeting and the Abstract is attached. |
