Record Display for the EPA National Library Catalog
RECORD NUMBER: 19 OF 38| Main Title | Methyl Methacrylate Monomer: Dominant Lethal Study in Mouse with Attachments and Cover Letter Dated 08/10/1989. | |||||||||||
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| CORP Author | ; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 1989 | |||||||||||
| Report Number | 86-890001507 | |||||||||||
| Stock Number | OTS0521246 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Methyl Methacrylate (80-62-6) ; Genotoxicity ; Chromosomal Effects ; Mammals ; Mice ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 80-62-6 | |||||||||||
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| Collation | 55p | |||||||||||
| Abstract | Genotoxicity of methyl methacrylate was evaluated in the dominant lethal test in the mouse. Male CD-1 mice (numbers not reported) received whole-body exposure to methyl methacrylate at vapor concentrations of 0, 100, 1000, or 9000 ppm, 6 hours/day for 5 days, then were mated with untreated females. Mortality rate increased in the high-dose group. The treatment had no adverse effects with respect to male fertility, pre-implantation loss, embryonic and fetal mortality, or conjoined placenta, indicating that methyl methacrylate was not genotoxic in this dominant lethal assay in mice. |