Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Support document, health effects test rule : chloromethane /
CORP Author United States. Environmental Protection Agency. Office of Toxic Substances. Assessment Division.
Publisher U.S. Environmental Protection Agency, Office of Pesticides and Toxic Substances,
Year Published 1980
Report Number EPA 560/11-80-015
Stock Number PB80-220304
OCLC Number 08453101
Subjects Methyl chloride. ; Environmental health--United States. ; Methyl Chloride--toxicity.
Additional Subjects Chloromethanes ; Toxicology ; Exposure ; Chlorohydrocarbons ; Chlorine organic compounds ; Physiological effects ; Assessments ; Laboratory animals ; Nervous system ; Signs and symptoms ; Testing ; Exposure ; Toxic substances ; Toxic Substances Control Act ; Public Law 94-469
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 560-11-80-015 Headquarters Library/Washington,DC 04/30/2012
EJED  EPA-560/11-80-015 OCSPP Chemical Library/Washington,DC 07/02/1999
ELBD RPS EPA 560-11-80-015 repository copy AWBERC Library/Cincinnati,OH 01/22/2020
ERAD  EPA 560/11-80-015 Region 9 Library/San Francisco,CA 09/04/2012
NTIS  PB80-220304 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 83 pages.
In 1979 approximately 497 million pounds of chloromethane were produced in the United States solely for domestic consumption. It is used almost exclusively as an intermediate, primarily in the manufacture of silicone and tetramethyllead. Chloromethane exposure has been reported to result in a wide range of systemic toxicity following both acute and chronic exposure. Although effects on the liver, kidney, heart, and hematopoietic system have been demonstrated in both humans and animals, the most sensitive organ seems to be the central nervous system (CNS). Chloromethane has been reported to possess mutagenic activity in bacterial systems that detect gene mutations and to cause chromosomal aberration. Evidence of its mutagenic activity, its in vitro and in vivo alkylating capabilities, and its structural relationship to known or suspected oncogens suggest that chloromethane may possess oncogenic potential. EPA is also concerned with the danger of both structural malformation and behavioral alterations that may be posed by chloromethane.
Cover title: Assessment of testing needs : chloromethane : support document for proposed health effects test rule, Toxic Substances Control Act, Section 4. "EPA-560/11-80-015." "June 1980." Includes bibliographical references (pages 67-83).