Record Display for the EPA National Library Catalog

RECORD NUMBER: 23 OF 33

OLS Field Name OLS Field Data
Main Title Oral Toxicity of Methyl Chloride with Cover Letter.
CORP Author Dow Chemical Co., Midland, MI.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 7 May 1940
Year Published 1940
Report Number 878210218;
Stock Number OTS-0206129
Additional Subjects Air pollution effects ; Carcinogenesis ; Toxicity ; Mammals ; Rats ; Mice ; Exposure levels ; Chloromethane ; Methyl chloride ; Chronic inhalation exposure ; CAS No. 74-87-3
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  OTS-0206129 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/29/2008
Collation 412p
Abstract
Aided by a consensus of member companies, methyl chloride was selected by CIIT as a commodity chemical which required comprehensive investigation of possible toxic and carcinogenic effects during chronic inhalation exposure in mammals. Such an investigation was planned and began with a ninety-day pilot study. The design and results of this latter study are the subject of this report. The Fischer-344 inbred rat and the BC Fl hybrid mouse were selected as the species and strains of choice because of a long life span; moreover, the widespread acceptance and usage of these animals in long-term toxicology research has generated a considerable background of data on spontaneous changes. This data could be employed in the future to resolve questionable toxicities. Inhalation exposure for 6 hours a day, 5 days each week, was used to stimulate the conditions of occupational usage of this agent. Decisions regarding the exposure levels to be administered during the initial pilot study were based upon information obtained from the literature or outside sources on file at the CIIT library.