| Main Title |
Mutagenic Assay of T-1716AC Aerosol with and without Metabolic Activation with Cover Letter. |
| CORP Author |
Industrial Bio-Test Labs., Inc., Northbrook, IL. ;Minnesota Mining and Mfg. Co., St. Paul.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
3 Dec 1982 |
| Year Published |
1982 |
| Report Number |
878211462; |
| Stock Number |
OTS-0205948 |
| Additional Subjects |
Toxicity ;
Aerosols ;
Air pollution ;
Bioassay ;
Rats ;
Liver ;
Methyl chloride ;
Assaying ;
Chemical compounds ;
Microsomes ;
Solvents ;
Trichloroethane ;
Testing ;
Mutagenicity tests ;
Metabolic activation
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0205948 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
19p |
| Abstract |
T-1716AC at a concentration of 1.9 gm (1 sec. discharge) in the absence of rat liver microsomes is moderately mutagenic. In the presence of metabolic activation the level of base-pair substitution is increased by a factor of 4 I/Z, approximately. No significant mutagenic effect occurred with T-716AC in the absence of the mammalian microsomes but a convincing evidence of mutagenic effect was obtained in the presence of rat liver microsomes. Methyl chloride used as a positive volatile control was highly mutagenic with or without the rat liver microsomes. 1, 1, 1-Trichloroethane is contained in. T-1716AC. However the concentration of this solvent is not indicated. |
