Record Display for the EPA National Library Catalog


Main Title Mutagenic Assay of T-1716AC Aerosol with and without Metabolic Activation with Cover Letter.
CORP Author Industrial Bio-Test Labs., Inc., Northbrook, IL. ;Minnesota Mining and Mfg. Co., St. Paul.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 3 Dec 1982
Year Published 1982
Report Number 878211462;
Stock Number OTS-0205948
Additional Subjects Toxicity ; Aerosols ; Air pollution ; Bioassay ; Rats ; Liver ; Methyl chloride ; Assaying ; Chemical compounds ; Microsomes ; Solvents ; Trichloroethane ; Testing ; Mutagenicity tests ; Metabolic activation
Library Call Number Additional Info Location Last
NTIS  OTS-0205948 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 19p
T-1716AC at a concentration of 1.9 gm (1 sec. discharge) in the absence of rat liver microsomes is moderately mutagenic. In the presence of metabolic activation the level of base-pair substitution is increased by a factor of 4 I/Z, approximately. No significant mutagenic effect occurred with T-716AC in the absence of the mammalian microsomes but a convincing evidence of mutagenic effect was obtained in the presence of rat liver microsomes. Methyl chloride used as a positive volatile control was highly mutagenic with or without the rat liver microsomes. 1, 1, 1-Trichloroethane is contained in. T-1716AC. However the concentration of this solvent is not indicated.