Record Display for the EPA National Library CatalogRECORD NUMBER: 2 OF 33
|Main Title||Chloroethane carcinogenicity : (CAS No. 75-00-3).|
|Author||Holder, J. W. ; Jinot, J.|
|CORP Author||Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.|
|Publisher||U.S. Environmental Protection Agency,|
|Report Number||NCEA-W-0018; EPA/600/R-95/099|
|Subjects||Methyl chloride--Toxicology ; Carcinogenicity testing ; Chloroethane--Toxicology ; Carcinogencity testing|
|Additional Subjects||Chlorobenzene ; Carcinogenicity tests ; Health effects ; Chlorobenzenes ; Carcinogens ; Health hazards ; Risk assessment ; Dose-respnse relationships ; Inhalation ; Rats ; Mice ; Malignant neoplasms ; Carcinoma ; Keratoachanthoma ; CAS 75-00-3 ; SAR(Structure-Activity Relationship)|
|Collation||34 pages : illustrations ; 28 cm|
Chloroethane (CE; CAS No. 75-00-3) is mutagenic in four tester strains of Salmonella typhimurium, plus and minus S9 activating fraction. Male rats responded with basal cell carcinomas, keratoacanthomas, squamous cell carcinomas, and trichoepitheliomas. Female rats showed brain astrocytomas at an incidence of 3/50 (6%) vs 0/50 (0%) controls vs 1/297 (0.3%) in historical controls. Female mice responded with malignant and metastasizing endo- and myo-metrial cancers. They spread to the lung, ovary, lymph nodes, kidney, adrenal gland, pancreas, mesentery, urinary bladder, spleen, and heart. The SAR, positive mutagenicity, and an exceptional degree and severity of carcinogenicity all indicate that CE causes cancer in rodents and is probably carcinogenic to similarly exposed humans.
"EPA 600/R-95/099." Includes bibliographical references. "National Center for Environmental Assessment." "April 1998." Microfiche.