Record Display for the EPA National Library Catalog
RECORD NUMBER: 10 OF 14| Main Title | Summary of Mortality Rates and Necropsy Observations of Tissue Masses and Nodules with Cover Sheet Dated 07/17/1989 (Sanitized). | |||||||||||
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| CORP Author | Hazleton Labs., Falls Church, VA.; Rohm and Haas Co., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 2000 | |||||||||||
| Report Number | 86-890001399S | |||||||||||
| Stock Number | OTS0521016 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Methyl Methacrylate (80-62-6) ; Chronic Toxicity ; Mammals ; Hamsters ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 80-62-6 | |||||||||||
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| Collation | 5p | |||||||||||
| Abstract | Chronic toxicity was evaluated in hamsters exposed to methyl methacrylate vapor at concentrations of 0, 25, 100, or 400 ppm for a period of 18 months. Mortality rates, after 64 weeks of treatment, in the control, low-, mid-, and high-dose groups were 12.5, 22.2, 16.1, and 28.6% (males) and 32.7, 33.9, 32.1 and 54.5% (females), respectively. The incidence of tissue masses or nodules noted at necropsy of animals found dead or moribund, in the control, low-, mid-, and high-dose groups, were 2/7, 1/12, 1/9, and 2/16 (males) and 2/18, 0/19, 1/18 and 3/30 (females) respectively. Results on statistical tests of these results were notreported. |