Record Display for the EPA National Library Catalog
RECORD NUMBER: 3 OF 6
|OLS Field Name||OLS Field Data|
|Main Title||Methyl Ethyl Ketone Toxicity Data Sheet prepared by Shell Chemical Corp. with Cover Letter.|
|CORP Author||Du Pont de Nemours (E.I.) and Co., Wilmington, DE. DuPont Environmental Remediation Services.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Publisher||4 Feb 1983|
|Additional Subjects||Toxicity ; Methyl ethers ; Ketones ; Gestation ; Dose response relationships ; Exposure ; Mortality ; Teratogenesis ; Inhalation ; Concentration ; Eye ; Vapors ; Body weight ; Industrial hygiene ; Responses(Biology) ; Central nervous system ; Methyl ethyl ketone(MEK) ; E I DuPont DeNemours and Co|
Pregnant Sprague-Dawley rats were exposed to 0, 400, 1000 or 3,000 ppm methyl ketone (MEK) on days 6 through 15 of gestation. Maternal toxicity, as evidenced by decreased weight gain and increased water consumption, was observed among rats exposed to 3,000 ppm MEK. Slight fetotoxicity was observed as evidenced by an increased incidence of some minor skeletal variants among litters from animals exposed to 3,000 pm MEK. No embryotoxic effects were observed. Although a slight fetotoxic effect and slight maternal toxicity were observed at the highest exposure level, MEK was not embryotoxic or teratogenic in rats at exposure levels up to 3,000 ppm.