Record Display for the EPA National Library Catalog


Main Title Acute Methanol Toxicity in Minipigs
Author Dorman, David C. ; Dorman, D. C. ; Dye, J. A. ; Nassise, M. P. ; Ekuta, J. ; Bolon, B.
Other Authors
Author Title of a Work
Dye, Janice A.
Nassise, Mark P.
Ekuta, Jethro
Bolon, Brad
Medinsky, Michele A.
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh. Coll. of Veterinary Medicine.
Publisher Environmental Protection Agency,
Year Published 1993
Report Number EPA/600/J-94/392;
Stock Number PB95-126520
OCLC Number 47171722
Subjects Methanol as fuel--toxicity
Additional Subjects Miniature swine ; Methanol ; Toxicity ; Animal disease models ; Eye(Anatomy) ; Central nervous system ; Dose-response relationships ; Pharmacokinetics ; Formic acid ; Reprints ;
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
ELCD  EPA 600-J-94-392 NVFEL Library/Ann Arbor, MI 09/09/2011
NTIS  PB95-126520 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 341-347p. : 28 cm.
The pig has been proposed as a potential animal model for methanol-induced neuro-ocular toxicosis in humans because of its low liver tetrahydrofolate levels and slower rate of formate metabolism compared to those of humans. To examine the validity of this animal model, 12 4-month-old female minipigs (minipig YU) were given a single oral dose of water or methanol at 1.0, 2.5, or 5.0 g/kg body wt by gavage (n = 3 pigs/dose). Dose-dependent signs of acute methanol intoxication, which included mild CNS depression, tremors, ataxia, and recumbency, developed within 0.5 to 2.0 hr, and resolved by 52 hr. Methanol- and formate-dosed pigs did not develop optic nerve lesions, toxicologically significant formate accumulation, or metabolic acidosis. Based on results following a single dose, female minipigs do not appear to be overtly sensitive to methanol and thus may not be a suitable animal model for acute methanol-induced neuroocular toxicosis.
"EPA/600/J-94/392" Includes bibliographical references.