Record Display for the EPA National Library Catalog


Main Title Update to the health assessment document and addendum for dichloromethane (methylene chloride) : pharmacokinetics, mechanism of action,and epidemiology.
Author Blancato, J. N. ; Hopkins, J. ; Rhomberg, L.
CORP Author United States. Environmental Protection Agency. Office of Research and Development.; Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment,
Year Published 1987
Report Number EPA 600/8-87/030A
Stock Number PB87228565
OCLC Number 16521888
Subjects Environmental health
Additional Subjects Environmental health ; Hazardous materials ; Industrial hygiene ; Toxicology ; Environmental surveys ; Carcinogens ; Chloromethanes ; Epidemiology ; Methane/dichloro ; DCM ; Methylene chloride ; Pharmacokinetics ; Toxic substances ; Cancer ; Occupational safety and health
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-8-87-030A Headquarters Library/Washington,DC 05/09/2014
EJBD  EPA 600-8-87-030A Headquarters Library/Washington,DC 08/19/2016
EJED  EPA 600/8-87-030A OCSPP Chemical Library/Washington,DC 01/01/1988
EKBD  EPA-600/8-87-030A Research Triangle Park Library/RTP, NC 01/01/1988
ERAD  EPA 600/8-87-030A Region 9 Library/San Francisco,CA 02/20/2013
ESAD  EPA 600-8-87-030A Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB87-228565 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xiii, 119 p. : ill. ; 28 cm.
The document represents EPA's analysis of the weight of evidence regarding the carcinogenic potential of dichloromethane (DCM, methylene chloride) for humans. It includes revised cancer risk estimates that take into account the newest information on pharmacokinetics, mechanism of action, and epidemiology, and it discusses, in some detail, methods for incorporating pharmacokinetic information into the cancer risk assessment. The document draws on the body of work developed by the Hazard/Risk Assessment Committee (HRAC) of the Integrated Chlorinated Solvents Project, an interagency workgroup. For the present, EPA scientists have used methods that result in an approximate ninefold reduction from previous unit estimates which were based on applied dose.
"EPA/600/8-87/030A." "Review draft." "July 1987."