| Main Title |
Update to the health assessment document and addendum for dichloromethane (methylene chloride) : pharmacokinetics, mechanism of action,and epidemiology. |
| Author |
Blancato, J. N. ;
Hopkins, J. ;
Rhomberg, L.
|
| CORP Author |
United States. Environmental Protection Agency. Office of Research and Development.; Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, |
| Year Published |
1987 |
| Report Number |
EPA 600/8-87/030A |
| Stock Number |
PB87228565 |
| OCLC Number |
16521888 |
| Subjects |
Environmental health
|
| Additional Subjects |
Environmental health ;
Hazardous materials ;
Industrial hygiene ;
Toxicology ;
Environmental surveys ;
Carcinogens ;
Chloromethanes ;
Epidemiology ;
Methane/dichloro ;
DCM ;
Methylene chloride ;
Pharmacokinetics ;
Toxic substances ;
Cancer ;
Occupational safety and health
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD ARCHIVE |
EPA 600-8-87-030A |
|
Headquarters Library/Washington,DC |
05/09/2014 |
| EJBD |
EPA 600-8-87-030A |
|
Headquarters Library/Washington,DC |
08/19/2016 |
| EJED |
EPA 600/8-87-030A |
|
OCSPP Chemical Library/Washington,DC |
01/01/1988 |
| EKBD |
EPA-600/8-87-030A |
|
Research Triangle Park Library/RTP, NC |
01/01/1988 |
| ERAD |
EPA 600/8-87-030A |
|
Region 9 Library/San Francisco,CA |
02/20/2013 |
| ESAD |
EPA 600-8-87-030A |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
| NTIS |
PB87-228565 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
xiii, 119 p. : ill. ; 28 cm. |
| Abstract |
The document represents EPA's analysis of the weight of evidence regarding the carcinogenic potential of dichloromethane (DCM, methylene chloride) for humans. It includes revised cancer risk estimates that take into account the newest information on pharmacokinetics, mechanism of action, and epidemiology, and it discusses, in some detail, methods for incorporating pharmacokinetic information into the cancer risk assessment. The document draws on the body of work developed by the Hazard/Risk Assessment Committee (HRAC) of the Integrated Chlorinated Solvents Project, an interagency workgroup. For the present, EPA scientists have used methods that result in an approximate ninefold reduction from previous unit estimates which were based on applied dose. |
| Notes |
"EPA/600/8-87/030A." "Review draft." "July 1987." |
