Record Display for the EPA National Library Catalog

RECORD NUMBER: 24 OF 24

Main Title

Toxicity of Mercuric Chloride to the Developing Rat Kidney. 3. Distribution and Elimination of Mercury during Postnatal Maturation.

Author

Daston, G. P. ; Rehnberg, B. F. ; Hall, L. L. ; Kavlock, R. J. ;

CORP Author

Health Effects Research Lab., Research Triangle Park, NC. ;Wisconsin Univ.-Milwaukee. Dept. of Biological Sciences.

Publisher

c1986

Year Published

1986

Report Number

EPA/600/J-86/480;

Stock Number

PB89-105456

Additional Subjects

Toxicology ; Mercuric chloride ; Rats ; Kidneys ; Dosage ; Metabolism ; Reprints ;

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB89-105456	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

11p

Abstract

Mercuric chloride is a potent nephrotoxin in the adult rat, but has little effect on newborns. Nephrotoxicity increases with postnatal maturation. The study assesses the changes in tissue distribution and excretion of Hg during postnatal development. Sprague Dawley rats were injected so with 5 mg/kg (203)HgCl2 on postnatal day 1, 8, 15, 22 or 29. Hg concentration was measured in the whole body, renal cortex, medulla and papilla, liver, and subcellular fractions of liver and kidney. Binding to cytosolic metallothionein was assessed.