Record Display for the EPA National Library Catalog


Main Title Immunologic Effects of Nickel: 2. Suppression of Natural Killer Cell Activity.
Author Smialowicz, R. J. ; Rogers, R. R. ; Riddle, M. M. ; Garner, R. J. ; Rowe, D. G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/011;
Stock Number PB85-198281
Additional Subjects Nickel ; Chlorides ; Laboratory animals ; Immunology ; Mice ; Dosage ; In vivo analysis ; Bioassay ; Neoplasms ; Melanoma ; Cells(Biology) ; Reprints ; Inteferon
Library Call Number Additional Info Location Last
NTIS  PB85-198281 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
A single intramuscular injection of nickel chloride (18.3 mg/kg) caused a significant reduction in murine splenic natural killer (NK) cell activity. This reduction in NK activity was not associated with a significant reduction in spleen cellularity nor in the production of suppressor cells. In a 4-hr 51Cr release assay, NK cell activity was suppressed in both CBA/J and C57BL/6J mice. Administration of the nickel dose (i.e., 18.3 mg/kg total) over a two week period also caused a significant reduction in NK cell activity. In an in vivo NK assay the clearance of 125I-iododeoxyuridine labeled YAC-1 tumor cells from the lungs of nickel-treated mice was significantly reduced compared with saline injected controls. Another in vivo correlate of nickel-induced NK suppression was observed in mice injected with the B16-F10 melanoma.