Revised edition of: DNA repair and mutagenesis / Errol C. Friedberg, Graham C. Walker, Wolfram Siede. c1995. Includes bibliographical references and index.

Introduction biological responses to DNA damage -- DNA damage -- Introduction to mutagenesis -- Reversal of base damage caused by UV radiation -- Reversal of alkylation damage in DNA -- Base excision repair -- Nucleotide excision repair: general features and the process in prokaryotes -- Nucleotide excision repair in eukaryotes: cell biology and genetics -- Mechanism of nucleotide excision repair in eukaryotes -- Heterogeneity of nuculeotide excision repair in eukaryotic genomes -- Alternative excision repair of DNA -- Mismatch repair -- Repair of mitochondrial DNA damage -- The SOS responses of prokaryotes to DNA damage -- Mutagenesis and translesion synthesis in prokaryotes -- Recombinational repair, replication fork repair, and DNA damage tolerance -- DNA damage tolerance and mutagenesis in eukaryotic cells -- Managing DNA strand breaks in eukaryotic cells: repair pathway overview and homologous recombination -- Managing DNA strand breaks in eukaryotic cells: nonhomologous end joining and other pathways -- Cell cycle checkpoints: general introduction and mechanisms of DNA damage sensing -- Cell cycle checkpoints: singal transmission and effector targets -- Transcriptional responses to DNA damage -- DNA damage and the regulation of cell fate -- Xeroderma pigmentosum: a disease associated with defective nucleotide excision repair or defective translesion DNA synthesis -- Other diseases associated with defects in nucleotide excision repair of DNA -- Diseases associated with defective responses to DNA strand breaks -- Diseases associated with disordered DNA helicase functions -- Additional diseases associated with defective responses to DNA damage -- Hereditary diseases that implicate defective responses to DNA damage -- DNA polymorphisms in gatekeeper and guardian genes. Completely reorganized, the new edition presents a significant overhaul of the existing chapters and introduces important new material, reflective of the major changes and developments that have occurred in the field over the last decade. As with the first edition, this new volume presents the field within a strong historical framework and all aspects of biological responses to DNA damage are detailed. The book consists of 30 chapters divided into five main parts, covering: sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage. Basic principles are appropriately stressed; however, the book focuses on the significant progress to date and future research directions.