Record Display for the EPA National Library Catalog


Main Title Computerized Assessment of Human Neurotoxicity: Sensitivity to Nitrous Oxide Exposure.
Author Greenberg, B. D. ; Moore, P. A. ; Letz, R. ; Baker, E. L. ;
CORP Author Harvard School of Public Health, Boston, MA.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-811896; EPA/600/J-85/375;
Stock Number PB86-187374
Additional Subjects Toxicology ; Nitrous oxide ; Assessments ; Exposure ; Computers ; Reprints ; Neurotoxicity ; Medical computer applications
Library Call Number Additional Info Location Last
NTIS  PB86-187374 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
The authors recently developed a flexible, portable, computer based neurobehavioral evaluation system (NES) to standardize data collection in epidemiologic field studies of individuals at risk for neurobehavioral toxicity. The current study was performed to examine the system's sensitivity to subtle neurobehavioral impairment induced pharmacologically in normal subjects. Twelve men 18 to 36 years old were tested with the NES three times, in an initial training session followed by separate drug and control sessions in randomized order. During drug sessions subjects received a combination of 20% nitrous oxide and 80% oxygen through a nasal mask. In control sessions subjects received 100% oxygen. Nine NES tests evaluating psychomotor performance, visuospatial ability, memory, and mood were administered in approximately 40 minutes. Nitrous oxide exposure impaired performance on three tests: continuous performance, symbol-digit substitution, and finger tapping. Another test, pattern memory, showed a trend toward impairment, while the remainder were not affected by the drug. These data are consistent with previous reports that the threshold effect of nitrous oxide is a decrement in psychomotor speed.