Record Display for the EPA National Library Catalog


Main Title Inhalation toxicology of airborne particulate manganese in Rhesus monkeys /
Author Coulston, Frederick ; Griffin., Travis
Other Authors
Author Title of a Work
Coulston, Frederick.
Griffin, Travis.
Knelson, John H.
Love, Gory J.
CORP Author Albany Medical Coll., N.Y. Inst. of Comparative and Human Toxicology. ;International Center of Environmental Safety, Holloman AFB, N. Mex.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1977
Report Number PB268643; EPA-600/1-77-026; EPA-68-02-0710
Stock Number PB-268 643
OCLC Number 52465208
Subjects Manganese ; Air--Pollution--Toxicology ; Air--Pollution--Toxicity ; Air pollutants--Toxicity
Additional Subjects Toxicology ; Manganese oxides ; Air pollution ; Toxicity ; Monkeys ; Experimental data ; Laboratory animals ; Aerosols ; Exposure ; Rats ; Tissues(Biology) ; Respiration ; Lung ; Absorption(Biology) ; Concentration(Composition) ; Hematology ; Pathology ; Tables(Data) ; Rhesus monkeys ; Pons ; Bioaccumulation ; Clinical chemistry ; Air pollution effects(Animals)
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJED  EPA 600/1-77/026 OCSPP Chemical Library/Washington,DC 07/01/2005
EKBD  EPA-600/1-77-026 Research Triangle Park Library/RTP, NC 06/17/2016
ELBD ARCHIVE EPA 600-1-77-026 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
NTIS  PB-268 643 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vi, 85 pages ; 28 cm.
Four male and four female rhesus monkeys were exposed to manganese oxide (Mn3O4) aerosol at 100 micrograms/cubic meter in an exposure chamber for periods up to 66 weeks. Three male and three female monkeys were maintained as unexposed controls. Observation and clinical chemistry during the experiment showed minor changes in excretion, and no evidence of toxic effects. Manganese tissue levels showed small increases except in lung (five-fold) and pons (four-fold). No macro- or microscopic pathology was observed. Two rhesus monkeys were exposed to 5 mg/cubic meter of the same material for 23 weeks, and observed for 10 months thereafter. Large increases in excretion of manganese were observed in both urine and feces, but no evidence of neurologic or other toxicity was seen. Two groups of 4 and of 14 rats were exposed in the same manner to 100 micrograms/cubic meters of the same compound for 8 weeks. These experiments were done to examine changes in excretion and tissue levels during and after exposure.
Project Officer: John H. Knelson and Gory J. Love. "May 1977." "EPA-600/1-77-026." PB 268 643--NTIS. Includes bibliographical references.