This document provides information on how to implement approved remedial response activities at National Priorities List sites in accordance with the National Oil and Hazardous Substances Contingency Plan. Its scope includes cooperative agreements, Superfund State Contracts and credit claims. Further, this document incorporates several new Superfund initiatives EPA has taken in the past year to facilitate remedial response and to make it easier for States to join EPA in addressing problems at uncontrolled hazardous waste sites. The document is intended to serve as a manual for State and EPA staff who are implementing the Superfund remedial program, consistent with the delegations of authority the authors plan to issue in the coming months. Until these delegations are approved, cooperative agreements, Superfund State Contracts and audit responses will be processed in Headquarters in accordance with current practice.