The report presents the results of six studies to analyze the variations in waste reduction requirements along a 180-mile reach of the Wisconsin River. The variation of waste reduction requirements is studied as a function of specified minimum concentrations of dissolved oxygen, levels of waste discharge by various sources, the designation of various uses for specified sub-reaches of the river, the risk that dissolved oxygen standard will be contravened, a priori policies such as primary treatment plus chlorination or secondary treatment for all municipalities, prior process changes for several industrial sources, turbine and mechanical aeration, and plans for redistribution of waste discharge points. The trade-offs between flow augmentation, waste reduction, recreation, and power are examined. It is concluded that a minimum cost waste reduction plan depends critically on the assumed bases, and thus it is necessary for the water quality management agency to carefully analyze the effect of these assumptions.