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RECORD NUMBER: 1906 OF 2096

Main Title Teratology Study in Rats with Lx1106-01 (Final Report) with Attachments and Cover Letter Dated 04/24/1991 (Sanitized).
CORP Author Bio-Dynamics Research and Development Corp., Eugene, OR.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1991
Report Number 86-910000809S
Stock Number OTS0529441
Additional Subjects Toxicology ; Health effects ; Solvent Naphtha (petroleum) Light Aromatic (64742-95-6) ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 64742-95-6
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NTIS  OTS0529441 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 404p
Abstract
Solvent Naphtha, light aromatic (C8-10) (CAS No. 64742-95-6) was evaluated for maternal and developmental toxicity. The test substance was administered by oral gavage to mice (24 mated females/group) on gestation days 6-15 at dose levels of 0, 125, 625, and 1,250 mg/kg/day. As compared to controls, animals treated with 125 mg/kg/day and above had a slightly increased incidence of excessive salivation. At 625 mg/kg/day and above, maternal weight gain and food consumption was significantly reduced, compared to controls. At 1,250 mg/kg/day, there was staining of the anogenital area, alopecia of the legs, reduced fetal weights, and increased incidence of skeletal malformations. No other embryotoxic or teratogenic effects were noted at any dose level.