Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Toxicological Investigationof Maleic Anhydride, Lot No. QB1151 with Cover Letter.
CORP Author Monsanto Co., St. Louis, MO.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1984
Report Number 878214766
Stock Number OTS-0206655
Additional Subjects Health effects ; Toxicity ; Laboratory animals ; Acute ; Lethal doses ; Signs and symptoms ; Dose levels ; Mammals ; Rats ; Oral ; Gavage ; Maleic anhydride ; CAS No 108-31-6
Library Call Number Additional Info Location Last
NTIS  OTS-0206655 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 10/16/2009
Collation 1288p
In an acute toxicity study, male and female Sprague-Dawley rats (2 males and 3 females/group, except highest-dose level group which had 4 males and 1 female) were given single gavage exposures to maleic anhydride (as a 10% solution/suspension in corn oil). Dose levels of 316, 398, 501, and 631 mg/kg resulted in the deaths of 0, 1, 3, and 4 animals, respectively (duration of observation period was not reported although the survival time was reported to be one to four days). The LD50 is 495 (410 to 580) mg/kg. Toxic symptoms observed included loss of appetite, diarrhea, and increasing weakness. Gross pathology observed at autopsy included renal and liver congestion, and inflammation of the gastric mucosa.