| Main Title |
Characterization of Doxylamine and Pyrilamine Metabolites via Thermospray/Mass Spectrometry and Tandem Mass Spectrometry. |
| Author |
Korfmacher, W. A. ;
Holder, C. L. ;
Betowski, L. D. ;
Mitchum, R. K. ;
|
| CORP Author |
Environmental Monitoring Systems Lab., Las Vegas, NV. ;National Center for Toxicological Research, Jefferson, AR. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/080; |
| Stock Number |
PB89-103576 |
| Additional Subjects |
Chemical analysis ;
Doxylamine ;
Pyrilamine ;
Cyclic N-oxides ;
Mass spectrometry ;
Metabolism ;
Pyridines ;
Macaca mulatta ;
Laboratory animals ;
Reprints ;
Tandem mass spectrometry ;
Thermospray mass spectrometry
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-103576 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Analysis of doxylamine N-oxide and pyrilamine N-oxide as synthetic standards and biologically derived metabolites by thermospray mass spectrometry (TSP/MS) provided (M + H)+ ions for each metabolite. TSP/tandem mass spectrometry (TSP/MS/MS) of the (M + H)+ ions provided fragment ions characteristic of these metabolites. In addition, TSP mass spectrometry and TSP/MS/MS analysis of ring-hydroxylated N-desmethyldoxylamine, N-desmethylopyrilamine and O-dealkylated pyrilamine is also reported. A fragmentation pathway for analysis by MS/MS of pyrilamine and its metabolites is also proposed. The results demonstrated the utility of TSP/MS for biologically derived metabolites of pyrilamine and doxylamine. (Copyright (c) 1988 by John Wiley & Sons Ltd.) |
