Record Display for the EPA National Library Catalog


Main Title 1-Chloromethylpyrene: A Reference Skin Sensitizer and Genotoxin.
Author Ashby, J. ; Gallagher, J. E. ; Kohan, M. ; Tinwell, H. ; Kimber., I. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Institut de Recherches Scientifiques sur le Cancer, Villejuif (France). ;Imperial Chemical Industries Ltd., Alderley Park (England). Central Toxicology Lab.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/174;
Stock Number PB91-115782
Additional Subjects Toxicology ; Mutagens ; Skin(Anatomy) ; Sensitizing ; Deoxyribonucleic acids ; Carcinogens ; Salmonella typhimurium ; Deoxyribonucleic acids ; Mice ; Lymph nodes ; Bone marrow ; Reprints ; 1-chloromethylpyrene ; Mutagenicity tests ; Micronucleus test ; Benzo(a)pyrene ; Biotransformation ; Contact dermatitis
Library Call Number Additional Info Location Last
NTIS  PB91-115782 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
1-Chloromethylpyrene has been evaluated as a model mutagen and toxin related to the ultimate electrophiles derived from BaP and 1-nitropyren. It was mutagenic to Salmonella (>100 picograms/plate) and exceptionally reactive to DNA when assessed by the postlabeling assay. 1-CMP was inactive in a mouse bone marrow micronucleus assay when administered by gavage probably due to hydroylis whose kinetics have been studied (half life 23 min at 37 C). However as expected it was a potent skin toxin as determined by its activity as a mitogen to mouse skin and its contact allergenicity, as determined using the local lymph node proliferative assay. It is concluded that 1-CMP will probably be a potent human skin carcinogen and contact allergen. (Copyright (c) 1990 Elsevier Science Publishers B.V. (Biomedical Division).)