Record Display for the EPA National Library Catalog


Main Title Lung Injury Caused by Ambient Levels of Ozone.
Author Huang, Y. ; Chang, L. Y. ; Miller, F. J. ; Crapo., J. D. ;
CORP Author Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher 1988
Year Published 1988
Report Number EPA-R-813113; EPA/600/J-88/554;
Stock Number PB91-117606
Additional Subjects Ozone ; Lung ; Injuries ; Rats ; Exposure ; Epithelium ; Reprints ; Air pollution effects(Animals) ; Lung volume measurements ; Pulmonary alveoli ; Macrophages
Library Call Number Additional Info Location Last
NTIS  PB91-117606 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Exposures to low levels of O3 cause epithelial and interstitial injury in the proximal alveolar region. The sequential development of this lesion caused by a simulated ambient pattern of O3 was studied by exposing Fisher 344 rats to 0.06ppm O3 overnight with an 8 hr daytime exposure having a slow increase to a peak of 0.25 ppm and then gradually decreasing back to 0.06 ppm. Animals were studied using EM morphometric techniques after 7, 21 and 90 days exposure as well as post 90 days exposures. The early changes in O3 exposed animals included increases of volumes in type II epithelium (60%), type I epithelium (16%), cellular interstitium (52%), non-cell interstitium (33%), and in alveolar macrophages (180%). The response showed a biphasic reaction with the early injury subsiding after 21 days of O3 exposure. The animals exposed for 90 days showed a 28% increase in relative volume of type I and a 42% increase in type II epithelia.