Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Macrophage Damage in Relation to the Pathogenesis of Lung Diseases.
Author Brain, Joseph D. ;
CORP Author Harvard School of Public Health, Boston, MA.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1980
Report Number EPA-R-805091; EPA-600/J-82-063;
Stock Number PB82-249269
Additional Subjects Pathology ; Respiratory diseases ; Migrations ; Behavior ; Reprints ; Lung diseases ; Macrophages ; Immune responses
Library Call Number Additional Info Location Last
NTIS  PB82-249269 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 10p
Pulmonary macrophages are important since their migratory patterns and behavior are often pivotal events in the pathogenesis of pulmonary disease. Alveolar macrophages act to decrease the probability of particle penetration through epithelial barriers, and their phagocytic and lytic potentials provide most of the known bactericidal properties of the lungs. Macrophages are also involved in immune responses and in defense against neoplasms. Increased inert or infectious particles stimulate the recruitment of additional macrophages. Most free cells containing particles eventually reach the airways and are quickly carried to the pharynx and swallowed.