| Main Title |
Dibromoethane Effects on the Induction of Gamma-Glutamyl-Transpeptidase Positive Foci in Rat Liver. |
| Author |
Milks, Michael M. ;
Wilt, Stephen R. ;
Ali, Ibrahim ;
Pereira, Michael A. ;
Couri, Daniel ;
|
| CORP Author |
Ohio State Univ., Columbus. Coll. of Medicine.;Health Effects Research Lab., Research Traingle Park, NC. |
| Year Published |
1982 |
| Report Number |
EPA-CR-807378; EPA-600/J-82-272; |
| Stock Number |
PB83-157552 |
| Additional Subjects |
Toxicology ;
Bioassay ;
Rats ;
Liver ;
Pathology ;
Ingestion(Biology) ;
Dosage ;
Reprints ;
Ethane/dibromo ;
Glutamyl transpeptidase
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-157552 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
The initiating and promoting activities of 1.2-dibromoethane in rat liver were investigated using the enzyme-altered foci bioassay. The incidence of gamma-glutamyl-transpeptidase (GGT)-positive foci was used as an early histochemical marker for hepatocarcinogenesis. To determine the initiating activity of 1.2-dibromoethane, the halogenated hydrocarbon was administered orally in corn oil as single or multiple doses (60 or 120 mg/kg) either before or after partial hepatectomy. The animals were then given a promoting regimen of 500 ppm phenobarbital in their drinking water. No increase in the incidence of GGT-positive foci was observed in any of the 1.2-dibromoethane initiation groups. |
