Record Display for the EPA National Library Catalog


Main Title Summary review of health effects associated with dimethylamine : health issue assessment /
Author Rothwell, C. E. ; Turck, P. ; Parker, D. ; Rowland, J. ; England, T.
CORP Author United States. Environmental Protection Agency. Environmental Criteria and Assessment Office (Research Triangle Park, N.C.).
Publisher Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1990
Report Number EPA/600-8-90-038F; ECAO-R-0149
Stock Number PB90-271909
OCLC Number 22745077
Subjects Dimethylamine--Toxicology ; Dimethylamine--Environmental aspects
Additional Subjects Dimethylamine ; Toxicity ; Public health ; Exposure ; Laboratory animals ; Metabolism ; Health hazards ; Risk assessment ; Air pollution effects(Animals) ; Air pollution effects(Humans) ; Pharmacokinetics ; Liver microsomes ; Dose-response relationships
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  QD305.A8S85 1990 Region 1 Library/Boston,MA 04/29/2016
EJED  EPA-600/8-90/038F OCSPP Chemical Library/Washington,DC 12/14/1990
EKBD  EPA-600/8-90-038F Research Triangle Park Library/RTP, NC 04/30/2004
EKCD  EPA/600/8-90/038F CEMM/GEMMD Library/Gulf Breeze,FL 09/04/2018
ELBD ARCHIVE EPA 600-8-90-038F Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023 DISPERSAL
EMBD  EPA/600/8-90/038F NRMRL/GWERD Library/Ada,OK 01/01/1988
ERAD  EPA 600/8-90-038f Region 9 Library/San Francisco,CA 11/15/2012
ESAD  EPA 600-8-90-038F Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB90-271909 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation viii, 64 pages : illustrations, figures, tables ; 24 cm
Chemical properties and toxicity studies for dimethylamine (DMA) are reviewed. At 25 C, DMA is a water-soluble, colorless, flammable gas, with both natural and anthropogenic sources. Body burden of DMA is due to rapid absorption of inhaled or ingested DMA, along with endogenous formation; urinary excretion of unmetabolized compound is primary route of elimination. Microsomal enzymes in nose and liver convert DMA to formaldehyde. DMA in the stomach in presence of nitrite and acid conditions can be converted to nitrosamines. Chronic inhalation studies in 2 or more species indicate concentration-dependent toxicity in nasal mucosa with no other tissues affected except small decrease in body weight at 175 ppm. There is no evidence for carcinogenicity, mutagenicity; there are no data on teratogenic or reproductive effects. Human data available are limited to secondary reports of eye irritation at low concentration, with nose, throat, and lung irritation at 100 ppm DMA. Skin or eye contact produces severe burns. Further data are needed on ambient levels and human effects.
"Shipping list no.: 90-720-P." "September 1990." Includes bibliographical references (pages 53-64).