Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Phthalate Esters Program Panel Voluntary Test Program Health Effects Testing Phase I: Validation Results Volume One and Two with Cover Memo.
Author Cox, G. V. ; Moran, E. J. ; Zoll, D. F. ;
CORP Author Chemical Manufacturers Association, Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 30 Oct 1982
Year Published 1982
Report Number FYI-AX-1282-0224;
Stock Number OTS-0000224-0
Additional Subjects Health effects ; Tests ; Genotoxicity ; Biological studies ; Testing ; Liver function tests ; Phthalate esters ; Metabolic studies ; Liver structure
Library Call Number Additional Info Location Last
NTIS  OTS-0000224-0 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 10/08/2007
Collation 839p
The Chemical Manufacturers Association Phthalate Esters Program Panel submitted a voluntary test program under Section 4 of the Toxic Substances Control Act to the Environmental Protection Agency on October 30, 1981. Volume II of that submission dealt with health effects of phthalate esters. Notification of the Program's acceptability was given by the Agency on January 5, 1982. The Health Effects Program is intended to give guidance regarding the level of concern over health effects due to phthalates, prioritize phthalates for further testing in terms of the effects of concern, and initiate such further testing as may be appropriate. Three types of testing were conducted: genotoxicity tests, biological studies focusing on liver structure and function, and metabolic studies. Testing is proceeding in two phases; Phase I consists of genotoxicity and biological studies with reference materials to provide validation and optimization of the proposed tests. Phase II would be performed on phthalate esters chosen to be representative of the major structural classes. Metabolic studies on di-2-ethylhexyl phthalate (DEHP) were also undertaken simultaneously with Phase I.