Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Acute, 14-Day Repeated Dosing, and 90-Day Subchronic Toxicity Studies of Carbon Tetrachloride in CD-1 Mice (Journal Version).
Author Hayes, J. R. ; Condie, L. W. ; Borzelleca, J. F. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology.
Publisher c1986
Year Published 1986
Report Number EPA/600/J-86/472;
Stock Number PB89-104004
Additional Subjects Carbon tetrachloride ; Toxicity ; Toxic substances ; Liver ; Pathology ; Mortality ; Laboratory animals ; Chlorine organic compounds ; Corn oil ; Dose-response relationships ; Hematology ; Enzymes ; Liver function tests ; Body weight ; Sex factors ; Organ weight ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB89-104004 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/14/1989
Collation 12p
CD-1 mice were utilized in 14-day repeated dosing and 90-day subchronic toxicity studies of carbon tetrachloride employing oral gavage with a corn-oil vehicle. The 14-day study used doses of 625, 1250 and 2500 mg/kg and the 90-day subchronic study used doses of 12, 120, 540 and 1200 mg/kg. The 14-day study revealed a dose dependent mortality and decreased body weight in males, whereas females demonstrated mortality only at the high dose. Other major findings were: decreased fibrinogen and lymphocytes, increased LDH, SGPT and SGOT, increased liver weight and decreased lung, thymus and kidney weights. No mortality was evident in the 90-day study. Decreased hemoglobin was evident in males and females and depressed hematocrits in females. LDH, SGPT, SGOT and ALP were increased: blood glucose levels decreased at all dosage levels. Liver and spleen weights were increased at all doses and thymus weights were increased in all but the two lower doses in females. Liver damage was observed at all doses in both sexes.