Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Distribution and Toxicological Effects of Inhaled Methyl Bromide in the Rat.
Author Jaskot, R. H. ; Grose, E. C. ; Most, B. M. ; Menache, M. G. ; Williams, T. B. ;
CORP Author Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. Inhalation Toxicology Group. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA-68-02-4032; EPA/600/J-88/543;
Stock Number PB91-109249
Additional Subjects Toxicology ; Rats ; Laboratory animals ; Exhaust emissions ; Public health ; Biochemistry ; Liver diseases ; Respiratory diseases ; Necrosis ; Carbon 14 ; Reprints ; Methyl bromide ; Inhalation ; Air pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB91-109249 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/04/1991
Collation 14p
Sixty day old male CD rats were exposed by nose only to (14)C-methyl bromide (55 ppm) for three minutes. The data indicated that the liver, lung, and kidney were the major organs of (14)C deposition immediately following exposure. Up to thirty-two hours following exposure, the major routes of excretion were pulmonary (14CO2) and renal with approximately 43% and 21% of the total inhaled radiolabel being eliminated, respectively. In separate experiments, 60 day old CD male rats were exposed by whole body inhalation for 6 hours/day for 1, 5, and 10 days to 30 ppm methyl bromide or control air. Following the 1 day exposure, glutathione (GSH) reductase activity in the liver showed an increase, while GSH S-transferase was significantly increased. Glucose-6-dehydrogenase (G-6-PDH) was increased and nonprotein sulfhydryl content was decreased in the kidney. After 5 days of exposure, GSH transferase activity was significantly increased, while G-6-PDH showed an increase in the lung. GSH reductase activity had decreased in the liver. After 10 days of exposure an increase in G-6-PDH activity was evident in the lung, and a significant decrease in GSH reductase and GSH S-transferase activities were found in the liver.