Record Display for the EPA National Library Catalog


Main Title Proliferative hepatocellular lesions of the rat : review and future use in risk assessment /
Author Rinde, Esther ; Hill, R. ; Chiu, A. ; Haberman, B.
Other Authors
Author Title of a Work
Chiu, Arthur.
Hill, Richard.
Haberman, Bernard.
CORP Author Environmental Protection Agency, Washington, DC. Office of Pesticides and Toxic Substances. ;Environmental Protection Agency, Washington, DC. Office of Research and Development.
Publisher U.S. Environmental Protection Agency, RiskAssessment Forum,
Year Published 1986
Report Number EPA/625/3-86/011
Stock Number PB87-178711
OCLC Number 16016127
Subjects Carcinogenicity testing
Additional Subjects Risk ; Liver neoplasms ; Carcinogens ; Malignant neoplasms ; Liver diseases ; Liver ; Neoplasms ; Rats
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJED  EPA/625/3-86/011 OCSPP Chemical Library/Washington,DC 01/26/2001
NTIS  PB87-178711 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vii, 22 p. : ill. ; 20 x 8 cm.
The paper addresses three questions that are crucial in the evaluation of rat tumor data and in the assessment of carcinogenic risk for humans. One question is whether to consider these lesions 'hyperplastic' or 'neoplastic' in nature, the latter classification being indicative of tumor formation. A second question is to interpret the finding that in some experimental systems, certain nonmalignant proliferative lesions may regress following removal of an inciting, carcinogenic stimulus, with only a small proportion of the lesions persisting. Finally, it is important to know whether any of these lesions may progress to carcinoma.
"February 1986." "EPA/625/3-86/011."--Cover. "In memory of Dr. Bernard Haberman