| Main Title |
Proliferative hepatocellular lesions of the rat : review and future use in risk assessment / |
| Author |
Rinde, Ester. ;
Hill, R. ;
Chiu, A. ;
Haberman, B.
|
| Other Authors |
|
| CORP Author |
United States. Enviornmental Protection Agency. Risk Assessment Forum. |
| Publisher |
Environmental Protection Agency, |
| Year Published |
1986 |
| Report Number |
EPA/625/3-86/011 |
| Stock Number |
PB87-178711 |
| OCLC Number |
15719293 |
| Subjects |
Risk assessment ;
Carcinogenicity testing
|
| Additional Subjects |
Risk assessment ;
Liver neoplasms ;
Carcinogens ;
Malignant neoplasms ;
Liver diseases ;
Liver ;
Neoplasms ;
Rats
|
| Internet Access |
|
| Local Library Info |
| Library |
Local Subject |
Local Note |
| EKB |
|
Photocopy. |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EHAM |
QL737.R6 p2 |
|
Region 1 Library/Boston,MA |
04/29/2016 |
| EIAD |
EPA/625/3-86/011 |
|
Region 2 Library/New York,NY |
10/02/2003 |
DISPERSAL |
| EJBD ARCHIVE |
EPA 625-3-86-011 |
|
Headquarters Library/Washington,DC |
01/25/2011 |
| EJBD |
EPA 625-3-86-011 |
|
Headquarters Library/Washington,DC |
09/25/2018 |
| EKBD |
EPA-625/3-86-011 |
|
Research Triangle Park Library/RTP, NC |
06/04/2012 |
| EKCD |
EPA/625/3-86/011 |
|
CEMM/GEMMD Library/Gulf Breeze,FL |
11/20/2018 |
| ERAD |
EPA 825/3-86-011 |
|
Region 9 Library/San Francisco,CA |
11/20/1998 |
| ESAD |
EPA 625-3-86-011 |
|
Region 10 Library/Seattle,WA |
05/31/2017 |
| NTIS |
PB87-178711 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
22 pages ; 28 cm |
| Abstract |
The paper addresses three questions that are crucial in the evaluation of rat tumor data and in the assessment of carcinogenic risk for humans. One question is whether to consider these lesions 'hyperplastic' or 'neoplastic' in nature, the latter classification being indicative of tumor formation. A second question is to interpret the finding that in some experimental systems, certain nonmalignant proliferative lesions may regress following removal of an inciting, carcinogenic stimulus, with only a small proportion of the lesions persisting. Finally, it is important to know whether any of these lesions may progress to carcinoma. |
| Notes |
"EPA/625/3-86/011." "February 1986." Includes bibliographical references (pages 18-22). |
