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Main Title Assessment of clinical procedures to evaluate liver intoxication in fish /
Author Gingerich, William H., ; Weber, Lavern J.
Other Authors
Author Title of a Work
Weber, Lavern J.,
CORP Author Oregon State Univ., Corvallis. Dept. of Fisheries and Wildlife.;Environmental Research Lab., Duluth, MN.
Publisher Environmental Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1979
Report Number EPA-600/3-79-088; EPA-R-803090
Stock Number PB80-101595
OCLC Number 05786694
Subjects Fishes--Effect of water pollution on--United States ; Rainbow trout ; Liver--Diseases ; Oncorhynchus mykiss ; Liver--Diseases--Diagnosis ; Liver function tests ; Rainbow trout--Diseases
Additional Subjects Toxicology ; Liver ; Fishes ; Evaluation ; Assessments ; Procedures ; Enzymes ; Biochemistry ; Physiology ; Exposure ; Toxicity ; Rainbow trout ; Toxic substances
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  SH174.G56 Region 1 Library/Boston,MA 04/29/2016
EJBD  EPA 600-3-79-088 Headquarters Library/Washington,DC 04/01/2014
ELBD ARCHIVE EPA 600-3-79-088 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD  EPA 600-3-79-088 AWBERC Library/Cincinnati,OH 04/10/1998
ELDD  EPA 600-3-79-088 CCTE/GLTED Library/Duluth,MN 05/24/2021
ESAD  EPA 600-3-79-088 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB80-101595 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xii, 106 pages : illustrations ; 28 cm.
Procedures were developed to clinically evaluate liver damage and liver function in rainbow trout following either acute intraperitoneal (i.p.) treatment or subacute bath exposure to selected mammalian hepatotoxic agents. Elevations in serum of liver specific enzymes such as aspartate aminotransferase (GOT), alanine aminotransferase (GPT) and alkaline phosphatase (AP) were investigated as potential indicators of hepatocellular damage. An exogenous test of liver function, plasma clearance of the organic anion sulfobromophthalein (BSP), also was investigated as a potentially useful test of overall liver function in the trout. The application of clinical tests to diagnose liver dysfunction in fishes following their exposure to environmental toxicants may be practical in controlled laboratory facilities. Despite the considerable variation that exists between groups of fish, significant differences could be demonstrated between control and treated fish. Variation among groups of fish make intergroup comparison of the field populations increasingly difficult by these methods. Therefore, the use of such techniques should be employed to evaluate liver toxicity under precisely controlled laboratory studies. Their application to field studies does not seem advisable.
"Physiological Effects of Pollution Section, Environmental Research Laboratory." "August 1979." Bibliographies: pages 94-105. Grant no.