Many different types of chemical protective clothing (CPC) are used to isolate workers at hazardous waste sites from contact with the potential hazards posed by chemical wastes. The study was performed to provide a more quantitative basis for making chemical protective clothing decisions. The study examined the cost and quality factors that influence the choice of CPC, and gathered data on different brands of CPC. The research consisted of three analyses conducted independently: a life-cycle cost analysis; an analysis of the quality of construction and sizing of Tyvek coveralls; and a survey of U.S. Environmental Protection Agency (EPA) personnel to pinpoint research and development needs for protective clothing other than ensembles and gloves. The study provides preliminary information on impact of various factors on clothing costs; design, quality, and sizing of a limited sample of Tyvek coveralls; and on the size, availability, and use problems associated with various types of CPC. Suggestions for future research provided.