||Does Iron or Heme Control Rat Hepatic Delta-Aminolevulinic Acid Synthetase Activity.
Kitchin, Kirk T. ;
Farmer, Jackie ;
||Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
Nitrogen organic compounds ;
Ethylene diamine/sodium-tetraacetate ;
Levulinic acid synthetase/amino ;
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Disodium ethylenediamine tetraacetic acid and/or allylisopropylacetamide administration to rat pups did not evoke a premature induction of hepatic d-aminolevulinic acid synthetase. Administration of iron to adult rats did not alter d-aminolevulinic acid synthetase activity and had little inductive effect on home oxygenase activity. Both heme and cobalt/dextran rapidly induced microsomal heme oxygenase by 3-8 fold. Induction of heme oxygenase by heme could be totally blocked by concurrent administration of cyclo-heximide. These results argue against the hypothesis that iron is the physiological mediator of d-aminolevulinic acid synthetase activity.