| Main Title |
Carcinogenic effects of Benzene : an update. |
| Author |
Bayliss, D. L. ;
Chen, C. ;
Sonawane, B. ;
Valcovic, L.
|
| CORP Author |
Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, |
| Year Published |
1997 |
| Report Number |
EPA/600/P-97/001A; NCEA-W-0268 |
| Stock Number |
PB97-188379 |
| OCLC Number |
37273183 |
| Subjects |
Benzene--Toxicology ;
Carcinogenesis ;
Benzene--toxicity ;
Carcinogens, Environmental
|
| Additional Subjects |
Benzene ;
Health effects ;
Risk assessment ;
Toxicity ;
Health hazards ;
Dose-response relationships ;
Environmental exposure pathway ;
Occupational exposure ;
Children ;
Pathogenesis ;
Metabolism ;
Malignant neoplasms ;
Mortality ;
Leukemia ;
Carcinogenicity
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EHAD |
EPA/600-P-97-001A |
|
Region 1 Library/Boston,MA |
08/15/1997 |
| EHBD |
EPA/600/P-97/001A |
|
CEMM/ACESD Library/Narragansett,RI |
02/23/2007 |
| EJED |
EPA 600/P-97-001A |
|
OCSPP Chemical Library/Washington,DC |
07/18/1997 |
| EKBD |
EPA-600/P-97-001A |
|
Research Triangle Park Library/RTP, NC |
12/19/1997 |
| EKCD |
EPA/600/P-97/001 |
|
CEMM/GEMMD Library/Gulf Breeze,FL |
10/02/2018 |
| ELBD ARCHIVE |
EPA 600/P-97/001A |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD |
EPA 600-P-97-001A |
|
AWBERC Library/Cincinnati,OH |
07/18/1997 |
| EMBD |
EPA/600/P-97/001A |
|
NRMRL/GWERD Library/Ada,OK |
09/27/1997 |
| ERAD |
EPA 600/P-97-001A |
|
Region 9 Library/San Francisco,CA |
11/20/1998 |
| ESAD |
EPA 600-P-97-001A |
|
Region 10 Library/Seattle,WA |
07/31/1998 |
| NTIS |
PB97-188379 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
v, 43 pages : illustrations ; 28 cm |
| Abstract |
The major issue addressed in this document involves the nature and magnitude of the risk of cancer to humans exposed to low levels of benzene. Occupational studies continue to provide the bulk of evidence of benzene's carcinogenicity. This document reconfirms that benzene is a known human carcinogen by all routes of exposure. This finding is supported by evidence from human epidemiologic studies, animal data, and an improvement in understanding of mechanisms of action. Human epidemiologic studies of highly exposed occupational cohorts have demonstrated that exposure to benzene can cause acute nonlymphocytic leukemia and other blood disorders, that is, preleukemia and aplastic anemia. Additionally, changes in blood and bone marrow consistent with hematoxicity are recognized in humans and experimental animals. Currently, there is insufficient evidence to reject a linear dose-response curve for benzene in the low dose region, i.e., that benzene is, in fact, nonlinear in its effects. Because this knowledge is not available at the present time, the Agency's approach of using a model with low dose linearity is still recommended. |
| Notes |
"EPA/600/P-97/001A."--Cover. "June 1997"--Cover. "Review Draft (Do Not Cite or Quote)"--Cover. "External Review Draft." "U.S. Environmental Protection Agency." Includes bibliographical references (pages 34-43). |
