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Main Title Three Generation Reproduction/Fertility Study in Rats with C9 Aromatic Hydrocarbons. Volumes 1-3. Draft with Attached Appendix and Cover Letter dated 05/15/89.
CORP Author International Research and Development Corp., Mattawan, MI. ;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 22 May 1989
Year Published 1989
Report Number FYI-OTS-0589-0693;
Stock Number OTS-0000693
Additional Subjects Rats ; Mortality ; Toxicity ; Body weight ; Food consumption ; Parturition ; Litter size ; Survival ; Growth ; C(sub 9)aromatic hydrocarbons ; Charles River CD rats ; Overt toxicity ; Fertility indices ; Gestation length ; Viable pups ; Stillborn pups
Library Call Number Additional Info Location Last
NTIS  OTS-0000693 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 780p
This report presents the data from a three generation reproduction/fertility study in Charles River CD(trademark) rats with C(sub 9) aromatic hydrocarbons. Desired concentrations of 100, 500 and 1,500 ppm were administered by whole body inhalation. The control group was exposed to filtered air. Thirty males and 30 females per group in the F(sub O) and F(sub 1) generations were exposed for 10 weeks prior to mating, while all F(sub 2) animals were exposed immediately following weaning, 10 to 12 weeks prior to mating. Thirty per sex of the surviving F(sub 2) animals were then selected for the breeding population. All parental animals and pups were observed for mortality and overt toxicity twice each day, seven day a week. Individual parental body weights and detailed clinical observations were recorded weekly, as was food consumption, except during the mating period. Maternal body weights and food consumption were recorded at specified intervals during gestation and lactation. Reproductive and litter parameters assessed included male and female fertility indices, the process of parturition, gestation length, litter size, numbers of viable and stillborn pups, and pup survival and growth during lactation. The average actual concentrations of the test article administered over the entire study to the low-, mid-, and high-dose groups were 103, 495 and 1,480 ppm, respectively.